Our lab studies protein post-translational modifications (PTMs), specifically how they affect protein structure, dynamics, and function (e.g. enzyme activity, altered protein-protein interactions), in addition to how PTMs are regulated. We are focusing on proteins associated with neurodegenerative and neuromuscular diseases.
We are very interested in studying non-canonical ubiquitination and other uncommon PTMs, such as citrullination/deimination. To address questions in these research areas, we use a variety of experimental and computational biophysical techniques, including biomolecular NMR, mass spectrometry, and simulations. See our research pages for more information.
If you are interested in joining our research program, please contact Prof. Castañeda! Our lab currently consists of a postdoc, three grad students, and two undergraduates. Interested undergraduate freshmen and sophomores are especially encouraged to apply.
Please note, this website is actively under construction. More material to be added soon.