Our review essay on the role of ubiquitin (Ub) in modulating phase separation of Ub-binding shuttle proteins was just published in BioEssays! In this piece, we review very recent findings on the ability of p62, hHR23B, and UBQLN2 to undergo liquid-liquid phase separation (LLPS). We review the underlying homotypic and heterotypic interactions that drive LLPS of these systems either with or without polyUb chains. We speculate on the biological functions of shuttle protein phase separation and how phase separation could promote protein degradation and other protein quality control processes. Follow the link here.
BioEssays review published!
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