Publications

Click here for a complete list. Here is a sampling of recent relevant publications:

Yang Y, Jones HB, Dao TP, Castañeda CA*. (2019) Single Amino Acid Substitutions in Stickers, but Not Spacers, Substantially Alter UBQLN2 Phase Transitions and Dense Phase Material Properties. J Phys Chem B 123: 3618-3629.

Dao TP, Martyniak B, Canning AJ, Lei Y, Colicino EG, Cosgrove MS, Hehnly H, Castañeda CA*. (2019) ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position and Amino Acid-Dependent Manner. Structure 27: 937-951.

        Featured commentary: Higgins N, Lin B, Monteiro MJ.                  (2109) Lou Gehrig’s Disease (ALS): UBQLN2 Mutations                Strike Out of Phase. Structure 27:879-881.

Riley JF, Dao TP, Castañeda CA*. (2018) Cancer mutations in SPOP put a stop to its intercompartmental hops. Molecular Cell 72: 1-3.

Dao TP, Kolaitis R-M, Kim HJ, O’Donovan K,  Martyniak B, Colicino E, Hehnly H, Taylor JP, Castañeda CA*. (2018) Ubiquitin modulates liquid-liquid phase separation of UBQLN2 via disruption of multivalent interactions. Molecular Cell 69: 965-978.

Featured commentary: Subudhi I, Shorter J. (2018) Ubiquilin 2: Shuttling clients out of phase? Molecular Cell. 69: 919-921.

Featured News & Views: Mittag T, Fawzi N. (2018) Protein quality and miRNA slicing get into phase. Nature Cell Biology. 20: 635-637.

Castañeda CA*, Dixon EK, Walker O, Chaturvedi A, Nakasone M, Curtis J, Reed M, Krueger S, Cropp TA, Fushman D. (2016) Linkage via K27 bestows ubiquitin chains with unique properties among polyubiquitins. Structure 24: 423-436.

Featured commentary: Di Lello P, Hymowitz SG. (2016) Unveiling the Structural and Dynamical Nature of the Ubiquitin Code. Structure. 24: 498-499.

Castañeda CA*, Chaturvedi A, Camara C, Curtis J, Krueger S, Fushman D. (2016) Linkage-specific conformational ensembles of non-canonical polyubiquitin chains. Phys. Chem. Chem. Phys. 18: 5771-5788.

Castañeda CA, Kashyap TR, Nakasone MA, Krueger S, Fushman D. (2013) Unique structural, dynamical, and functional properties of K11-linked polyubiquitin chains. Structure. 21: 1168-1181.

Featured commentary: Cunningham CN, Corn JE. (2013) Decoding a Chain Letter for Degradation. Structure. 21: 1068-1070.

Berlin K, Castañeda CA, Schneidman-Duhovny D, Sali A, Nava-Tudela A, Fushman D. (2013) Recovering a representative conformational ensemble from underdetermined macromolecular structural data, J. Am. Chem. Soc. 135: 16595-16609.

Castañeda CA, Liu J, Chaturvedi A, Nowicka U, Cropp TA, Fushman D. (2011) Nonenzymatic assembly of natural polyubiquitin chains of any linkage composition and isotopic labeling scheme. J. Am. Chem. Soc. 133: 17855-17868.

Castañeda CA, Spasser L, Bavikar SN, Brik A, Fushman D. (2011) Segmental isotopic labeling of ubiquitin chains to unravel monomer-specific molecular behavior. Angew Chem. Int. Ed. Engl. 50: 11210-11214.

Castañeda CA, Liu J, Kashyap TR, Singh RK, Fushman D, Cropp TA. (2011) Controlled enzymatic synthesis of natural-linkage, defined-length polyubiquitin chains using lysines with removable protecting groups. Chem Commum (Camb) 47: 2026-2028.

Collaborations:

  • Ha JH, Karchin, JM, Walker-Kopp, N, Castañeda, CA & Loh, SN.  (2015)  Engineered domain swapping as an on/off switch for protein function.  Chemistry & Biology, 22:1384-93.