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We are very excited to share our latest work with the Kraut lab. Here, we explored the functional consequences of UBQLN2 phase separation with an in vitro system containing ubiquitinated substrates, UBQLN2, and proteasomes or different DUBs.

We are happy to contribute to this great effort to decipher to effects of ALS-linked mutations on aggregation propensity and neurotoxicity. Read more here.

Nirbhik and Carlos represented the lab with a poster presentation and platform talk. We are very excited for all the new ideas and collaborations that came out of this wonderful meeting.

Carlos is excited to attend the Keystone Symposia on Ubiquitin Biology and Disease to learn all about the new discoveries in the Ub field as well as to present our latest work the effects of UBQLN2 on the degradation of ubiquitinated substrates by the proteasomes and DUBs.

Our postdocs Anitha and Billy represented the lab at ASCB and showcased our work in understanding the effects of different cellular stresses on the localization of UBQLN2.

We are very excited to share our surprising findings that the charge states of short intrinsically disordered regions UBQLN1, UBQLN2 and UBQLN4 greatly affect the phase transitions of these proteins. Because of this, addition of commonly used charged epitope tags also leads to changes in the phase transitions of UBQLNs. Our study has significant implications […]

We had a blast designing and working with a large library to polyubitquitin chains to tease out how chain architecture and conformation affect UBQLN2 phase transitions. This work is in collaboration with Jeremy Schmit who developed an analytical model to describe our experimental observations. Check out this work here.

This summer/fall, we welcome new postdoc Nirbhik, rotation student Sydney and undergrad Alana to the lab. We are very excited for some wonderful science to come!

This summer, we say goodbye to postdoc Sarasi and lab technician Bridget as they move on to new exciting stages of their lives and scientific careers. We will miss them dearly and wish them the very best! Despite an AQI of 160 due to Canadian wildfires, we had a great lab outing to celebrate Sarasi […]

The Beveridge and Castañeda groups join our expertise in IM-MS and UBQLN2 to explore the conformational changes of intrinsically disordered proteins in response to conditions that promote or inhibit LLPS. Check out this work here.